Cerium depresses endocardial endothelial cell-mediated proliferation of cardiac fibroblasts

Kuruvilla, Leena ; Kartha, Chandrasekharan Cheranellore (2006) Cerium depresses endocardial endothelial cell-mediated proliferation of cardiac fibroblasts Biological Trace Element Research, 114 (1-3). pp. 85-92. ISSN 0163-4984

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Official URL: http://www.springerlink.com/content/816p1618140104...

Related URL: http://dx.doi.org/10.1385/BTER:114:1:85

Abstract

Cerium has been implicated in the pathogenesis of cardiac disorders such as acute myocardial infarction and endomyocardial fibrosis (EMF). A geochemical hypothesis for the causation of EMF linked the cardiac lesions to magnesium deficiency consequent to malnutrition and increased cardiac levels of cerium derived from monazite soils in the coastal regions of the tropics. We tested the hypothesis that the stimulus for fibroblast proliferation and enhanced collagen synthesis in EMF is derived from cardiac endothelial cells activated or injured by cerium. We explored whether endocardial endothelial cells exposed to cerium secrete factors responsible for the increased proliferation and collagen synthesis in cardiac fibroblasts. Our results suggest that the growth response of cardiac fibroblasts to cerium is not mediated through growth factors secreted by endocardial endothelium and that the cardiac lesions in EMF result from direct stimulation of subendocardial fibroblasts by cerium.

Item Type:Article
Source:Copyright of this article belongs to Springer-Verlag.
ID Code:18177
Deposited On:17 Nov 2010 13:02
Last Modified:28 Feb 2011 04:58

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