Kara, Moumita ; Basak, Amit ; Bhattacharjee, Manish (2006) Synthesis and reactivity of cyclam-based enediynes Tetrahedron Letters, 47 (1). pp. 117-120. ISSN 0040-4039
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00404...
Related URL: http://dx.doi.org/10.1016/j.tetlet.2005.10.125
Abstract
Cyclam-based enediynes 1-3 have been synthesized for the first time either by direct bis- or tetra-alkylation of the cyclam or via double alkylation of the 1,8-bis-sulfonyl derivative. The enediyne 1 readily forms a complex with Ni(II), which also lowered the onset temperature for Bergman cyclization of the parent enediyne by 60°C. In the presence of a co-oxidant, MMPP, the Ni-complex can cleave ds-DNA into the nicked relaxed form at micromolar concentrations.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Cyclam; Enediyne; Calorimetry; Cyclization; Cleavage |
| ID Code: | 1754 |
| Deposited On: | 05 Oct 2010 11:13 |
| Last Modified: | 13 Jan 2011 09:44 |
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