Basak, Amit ; Rudra, Kakali Rani ; Bdour, Hussam Moh'd ; Dasgupta, Jyotishman (2001) Active site geometry of porcine pancreatic lipase: an interesting switchover from Jones' to Seebach's model Bioorganic & Medicinal Chemistry Letters, 11 (3). pp. 305-307. ISSN 0960-894X
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S09608...
Related URL: http://dx.doi.org/10.1016/S0960-894X(00)00675-2
Abstract
Porcine pancreatic lipase (PPL)-catalyzed hydrolysis of cis 3-acetoxyethyl-1,4-diphenyl and cis 3-acetoxyethyl-1-phenyl-4-(2-furyl) β-lactams 1a and 1b proceeded with opposite stereoselectivity while the corresponding thienyl β-lactam 1c showed no selectivity at all. An explanation based upon the dominance of hydrophobic and polar pockets in governing the stereoselectivity has been proposed.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 1745 |
| Deposited On: | 05 Oct 2010 11:15 |
| Last Modified: | 05 Oct 2010 11:15 |
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