Selvakumar, N. ; Raheem, Mohammed A. ; Khera, Manoj Kumar ; Rajale, Trideep V. ; Kumar, Magadi Sitaram ; Kandepu, Sreenivas ; Das, Jagattaran ; Rajagopalan, R. ; Iqbal, Javed ; Trehan, Sanjay (2003) Influence of ethylene-Oxy spacer group on the activity of linezolid: synthesis of potent antibacterials possessing a thiocarbonyl group Bioorganic & Medicinal Chemistry Letters, 13 (23). pp. 4169-4172. ISSN 0960-894X
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S09608...
Related URL: http://dx.doi.org/10.1016/j.bmcl.2003.08.068
Abstract
The influence of an ethylene-oxy spacer element between the heterocycle and the aromatic ring in linezolid is reported. The introduction of such spacer group generated compounds with inferior antibacterial activity. However, the conversion of the acetamide group present in the linezolid analogues to either thiocarbamate or thioacetamide functionality restored the activity. The synthesis of linezolid analogues possessing the ethylene-oxy spacer group along with SAR studies with different heterocycles and preparation of some thiocarbonyl compounds possessing potent antibacterial property are presented.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 17084 |
| Deposited On: | 16 Nov 2010 08:32 |
| Last Modified: | 17 Feb 2011 04:39 |
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