Shah, S. S. ; Kulkarni, M. G. ; Mashelkar, R. A. (1990) Zero-order release of pendent substituted active ingredients from swollen hydrogel matrices Journal of Controlled Release, 12 (2). pp. 155-158. ISSN 0168-3659
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/016836...
Related URL: http://dx.doi.org/10.1016/0168-3659(90)90091-7
Abstract
Release of active ingredients from rubbery matrices is known to follow the well-established Higuchi relationship. However, the release of p-nitrobenzoic acid from a swollen hydrogel matrix in which the moiety is covalently linked to the pendent chain of 2-hydroxyethyl methacrylate folhws zero-order release kinetics. The results have been explained on the basis of the structural changes in the matrix.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Controlled Release Society. |
| Keywords: | Hydrogels; Zero Order Release; Time Dependent Diffusivity; Pendent Chain System; Matrix Devices |
| ID Code: | 17083 |
| Deposited On: | 16 Nov 2010 08:33 |
| Last Modified: | 04 Jun 2011 08:33 |
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