Prabhakaran, E. N. ; Nageswara Rao, I. ; Boruah, Anima ; Iqbal, Javed (2002) Synthesis of small cyclic peptides via reverse tTurn induced ring closing metathesis of tripeptides Journal of Organic Chemistry, 67 (23). pp. 8247-8250. ISSN 0022-3263
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Official URL: http://pubs.acs.org/doi/abs/10.1021/jo0200320
Related URL: http://dx.doi.org/10.1021/jo0200320
Abstract
A reverse turn induced (γ/β-turn) cyclization of tripeptides 1 can be performed in a ring closing metathesis reaction with Grubbs' catalyst to the corresponding cyclic peptides 2. These cyclic peptides may be useful probes as a conformationally constrained mimic of the bioactive conformation of structurally related HIV protease inhibitors.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| ID Code: | 16977 |
| Deposited On: | 16 Nov 2010 13:13 |
| Last Modified: | 17 Feb 2011 04:58 |
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