Kundu, Manikuntala ; Basu, Joyoti ; Fujimagari, Micael ; Williamson, Patrick ; Schlegel, Robert Allen ; Chakrabarti, Parul (1991) Altered erythrocyte protein kinase C activity and membrane protein phosphorylation in chronic myelogenous leukemia Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1096 (3). pp. 205-208. ISSN 0925-4439
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/092544...
Related URL: http://dx.doi.org/10.1016/0925-4439(91)90006-U
Abstract
The membrane protein kinase C (PKC) content was found to be higher in erythrocytes form patients suffering from chronic myelogenous leukemia (CML) compared to normal erythrocytes. PKC activity was also higher in the cytosol and after translocation to the membrane, as assessed by histone phosphorylation. The increased PKC activity in CML erythrocytes was associated with abnormal phosphorylation of protein 4.1. Since phosphorylation-dephosphorylation mechanisms are likely candidates for controlling membrane protein associations, the altered PKC activity may be one of the factors responsible for altered thermal sensitivity and mechanical stability of CML erythrocytes.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Protein Kinase C; Erythrocyte Membrane; Protein Phosphorylation; Chronic Myelogenous Leukemia |
| ID Code: | 1679 |
| Deposited On: | 05 Oct 2010 09:48 |
| Last Modified: | 17 Jan 2011 08:22 |
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