Protein backbone interaction with nucleic acid base pairs: a theoretical investigation

Abstract

A novel model of interaction between peptide backbone and nucleic acid base pairs, proposed earlier on the basis of model building studies has been theoretically investigated. Interaction energies for two different schemes of H-bond interaction between peptide backbone and base pairs A-U and G-C have been calculated for different conformations of peptide backbone. The different H-bond parameters have been calculated. The importance of such an interaction in specific recognition has been discussed in light of the results of theoretical calculations.