PPL-catalysed hydrolysis of 3,4-disubstituted β-lactams: effect of chain length and stereochemistry on the enantioselectivity

Basak, Amit ; Bhattacharya, Gautam ; Bdour, Hussam M. M. (1998) PPL-catalysed hydrolysis of 3,4-disubstituted β-lactams: effect of chain length and stereochemistry on the enantioselectivity Tetrahedron, 54 (23). pp. 6529-6538. ISSN 0040-4020

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00404...

Related URL: http://dx.doi.org/10.1016/S0040-4020(98)00313-5

Abstract

3,4-Disubstituted β-lactam acetates 1a-15a have been subjected to PPL-catalysed hydrolysis. The stereochemical course of hydrolysis has been shown to depend upon the C3-C4 relative stereochemistry and the length of the chain bearing acetate functionality.

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