Kanwar, S. S. ; Lumba, K. ; Gupta, S. K. ; Katoch, V. M. ; Singh, P. ; Mishra, A. K. ; Kalia, S. B. (2008) Synthesis and mycobactericidal properties of metal complexes of isonicotinoyldithiocarbazic acid Biotechnology Letters, 30 (4). pp. 677-680. ISSN 0141-5492
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Official URL: http://www.springerlink.com/content/t26433n150n777...
Related URL: http://dx.doi.org/10.1007/s10529-007-9601-5
Abstract
An isonicotinoyldithiocarbazic acid (IN-DtczH) ligand, synthesized from isoniazid, was complexed with transition metals and evaluated for anti-mycobacterial activity as well as toxicity towards human-transformed rhabdomyosarcoma (RD) cells in vitro. Complexes with Ni, Co and Zn showed MIC of 2, 2 and 50 μg/ml against Mycobacterium tuberculosis H37Rv, and 10, 100 and 50 μg/ml against a multidrug-resistant strain of M. tuberculosis. They had little cytotoxic effect on the RD cells. In contrast, the Cu complex was highly cytotoxic with a low anti-mycobacterial activity.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Springer-Verlag. |
| Keywords: | Cytotoxicity; Metal-isonicotinoyldithiocarbazic Acid Complexes; Mycobactericidal Activity |
| ID Code: | 16674 |
| Deposited On: | 15 Nov 2010 13:28 |
| Last Modified: | 04 Jun 2011 08:47 |
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