Chaindy, G. B. N. ; Kanungo, M. S. (1976) Sex and age dependent response of pyruvate kinase of the brain of the rat to estradiol and testosterone Biochemical and Biophysical Research Communications, 72 (3). pp. 777-781. ISSN 0006-291X
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00062...
Related URL: http://dx.doi.org/10.1016/S0006-291X(76)80200-8
Abstract
Effects of estradiol and testosterone on pyruvate kinase of the cerebral hemisphere of 7-, 38- and 78-week old male and female rats were studied. The activity of the enzyme is highest in immature rats of both the sexes and decreases thereafter. Castration decreases its activity in all the ages of both the sexes except in adult males. Estradiol induces the enzyme in castrated rats of both the sexes of the three ages. However, the pattern of induction differs with dose and sex of the animal. Testosterone has no striking effect on the enzyme level of both sexes. There findings are discussed in relation to the differential responsiveness of genes at various phases of the life span of the rat.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 16391 |
| Deposited On: | 15 Nov 2010 13:44 |
| Last Modified: | 03 Jun 2011 09:23 |
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