Agarwal, Kirti ; Bali, Anu ; Gupta, C. M. (1986) Influence of the phospholipid structure on the stability of liposomes in serum Biochimica et Biophysica Acta (BBA) - Biomembranes, 856 (1). pp. 36-40. ISSN 0005-2736
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/000527...
Related URL: http://dx.doi.org/10.1016/0005-2736(86)90006-4
Abstract
The effect of serum on the structural integrity of liposomes consisting of ether and/or carbamyl analogs of 1,2-diester phosphatidylcholine (PC) has been evaluated by measuring both the efflux of the entrapped 6-carboxyfluorescein and the lipid transfer to serum proteins, and the results have been compared with the egg PC liposomes. Replacement of the C-1 ester bond in PC by an ether linkage did not significantly enhance the liposome stability, but it was markedly increased upon introducing further structural changes in the C-2 ester region of the resulting 1-ether-2-ester PC. However, the stability was not influenced by altering the steric configuration of the latter phospholipid. These results strongly suggest that lysis of liposomes in serum can be prevented by structurally modifying the ester bond(s) in the phospholipid component of liposomes.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Liposome Stability; Drug Delivery; Lipid Transfer; Plasma-induced Leakage; Phosphatidyl Analog |
| ID Code: | 15986 |
| Deposited On: | 16 Nov 2010 13:37 |
| Last Modified: | 03 Jun 2011 04:47 |
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