Arankalle, Vidya A. ; Chadha, Mandeep S. ; Chobe, Leenata P. ; Nair, Rekha ; Banerjee, Kalyan (1995) Cross-challenge studies in rhesus monkeys employing different Indian isolates of hepatitis E virus Journal of medical virology, 46 (4). pp. 358-363. ISSN 0146-6615
Full text not available from this repository.
Official URL: http://www3.interscience.wiley.com/journal/1121937...
Related URL: http://dx.doi.org/10.1002/jmv.1890460411
Abstract
The aim of this study was to determine if rhesus monkeys infected with one isolate of hepatitis E virus (HEV) were immune to subsequent challenge with other isolates of the virus. Three epidemic and one sporadic Indian HEV isolates were employed in the study. The interval between primary inoculation and challenge varied from 1 year and 6 months to 2 years and 9 months. Evidence of HEV infection was ascertained by rise in serum alanine transaminase (ALT) levels and/or seroconversion to antibodies to HEV (anti-HEV), and the presence of HEV-RNA in the bile or faeces of the infected monkeys. No evidence for multiplication of virus in monkeys challenged with different HEV isolates was obtained. These results show that immunity generated by one isolate of HEV protects against different isolates of hepatitis E virus.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to John Wiley and Sons, Inc. |
| Keywords: | HEV Isolates; PCR; Anti-HEV titres ; Cross-challenge |
| ID Code: | 15796 |
| Deposited On: | 13 Nov 2010 12:32 |
| Last Modified: | 25 Jun 2012 15:07 |
Repository Staff Only: item control page
