Time course and development of electro-clinical features in relation to pentylenetetrazol thresholds in monkeys with focal seizures

Abstract

Seizure manifestations occurred concurrently with significantly increased focal EEG abnormalities and significantly lowered pentylenetetrazol thresholds in monkeys, 69 ± 2 days following standardized aluminium hydeoxide injections into motor cortical sites in both hemispheres. Seizure occurence, chemical threshold and EEG changes tended to stabilize after 145 ± 5 days. Onset of epileptic changes occured significantly faster in monkeys with motor cortical foci in both hemispheres rather than in those with unilateral foci. Focal EEG changes, viz. spike density, was inversely correlated with pentylenetetrazol thresholds to a highly significant extent.