Kaul, C. L. ; Grewal, R. S. (1972) Antihypertensive and monoamine oxidase inhibitory activity of 3-amino-2-oxazolidinone (3AO) and its condensation product with 2-substituted-3-formyl-4-oxo-(4H) pyrido(l,2-a)pyrimidines Biochemical Pharmacology, 21 (3). pp. 303-314. ISSN 0006-2952
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/000629...
Related URL: http://dx.doi.org/10.1016/0006-2952(72)90342-5
Abstract
Some pharmacological and biochemical properties of 3-amino-2-oxazolidinone (3AO) and its condensation products with 2-substituted-3-formyl-4-oxo(4H)-pyrido (l,2-a)pyrimidines are described. All these compounds showed powerful antihypertensive and monoamine oxidase (MAO) inhibitory properties. In some cases both these activities were two to four times those of pargyline. Although these compounds were powerful MAO inhibitors in vivo, they were inactive in vitro. Pretreatment with SKF525A failed to show any significant effect on the MAO inhibition produced by these compounds (except Compound A). The correlation between the antihypertensive and MAO inhibition was not very good.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 15527 |
| Deposited On: | 13 Nov 2010 09:12 |
| Last Modified: | 02 Jun 2011 06:30 |
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