Arya, V. P. ; Grewal, R. S. ; Kaul, C. L. ; Ghate, S. P. ; Mehta, D. V. ; George, T. (1969) Antihypertensive agents II: synthesis and hypotensive activity of certain 1,4,5-trisubstituted pyrazoles Journal of Pharmaceutical Sciences, 58 (4). pp. 432-440. ISSN 0022-3549
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Official URL: http://onlinelibrary.wiley.com/doi/10.1002/jps.260...
Related URL: http://dx.doi.org/10.1002/jps.2600580409
Abstract
The preparation of a series of 1,4,5-trisubstituted pyrazoles is described. These compounds have been screened for their hypotensive and adrenolytic properties. The anti-hypertensive activity of one of the compounds, 1-[5-methyl-1-(2-quinoxalyl)-4-pyrazolyl]-3-[4-(o-tolyl)-piperazinyl]-1-propanone hydrochloride has been studied in detail.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Pharmaceutical Association. |
| Keywords: | Antihypertensive Agents-synthesis, Activity; 1, 4, 5-trisubstituted Pyrazoles-synthesis; Hypotensive; Adrenolytic Activity-1, 4, 5-trisubstituted Pyrazoles; UV Spectrophotometry-structure; NMR Spectroscopy-structure |
| ID Code: | 15515 |
| Deposited On: | 13 Nov 2010 09:10 |
| Last Modified: | 02 Jun 2011 06:31 |
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