Yadav, A. K. ; Yadav, S. K. S. ; Siddiqui, I. ; Peruncheralathan, S. ; Ila, H. ; Junjappa, H. (2008) A new one-pot, three-component synthesis of 2,3,5-substituted or annulated-6-(methylthio)pyridines Synlett, 2008 (17). pp. 2674-2680. ISSN 0936-5214
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Official URL: https://www.thieme-connect.com/ejournals/abstract/...
Related URL: http://dx.doi.org/10.1055/s-0028-1083529
Abstract
A new one-pot, three-component synthesis of 2,3,5-substituted (or 2,3-annulated)-6-(methylthio)pyridines by reacting acyclic or cyclic active methylene ketones, ammonium acetate, and bis(methylthio)acrolein (1) or its 2-phenyl analogue 8 (as 3-carbon-1,3-biselectrophilic components) in the presence of either AcOH-TFA (4:1) or ZnBr2 (or ZnI2) catalysts has been reported.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Thieme Medical Publishers Inc. |
| Keywords: | Pyridines; Cycloannulation; One-pot; Three-component Synthesis; Bis(methylthio)acrolein; Ammonium Acetate |
| ID Code: | 15414 |
| Deposited On: | 13 Nov 2010 08:52 |
| Last Modified: | 03 Jun 2011 04:35 |
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