Agrawal, Prashansa ; Barthwal, Sudhir Kumar ; Govil, Girjesh ; Barthwal, Ritu (2009) Solution studies on the complex of 4'-epiadriamycin-d-(CGATCG)2 followed by time-resolved fluorescence measurement, diffusion ordered spectroscopy and restrained molecular dynamics simulations Bioorganic & Medicinal Chemistry, 17 (7). pp. 2793-2811. ISSN 0968-0896
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S09680...
Related URL: http://dx.doi.org/10.1016/j.bmc.2009.02.032
Abstract
4'-Epiadriamycin is a better-tolerated anthracycline drug, due to lesser cardiotoxicity. We report here a study of the 2:1 complex of 4'-epiadriamycin-d-(CGATCG)2 by proton Nuclear Magnetic Resonance Spectroscopy which show the absence of sequential connectivities between C1pG2 and C5pG6 base pair steps and presence of intermolecular cross peaks of the drug and DNA. Our studies establish the role of 9OH, NH3, 7O, 4OCH3 groups in binding to DNA. Time-resolved fluorescence measurement and diffusion ordered spectroscopic studies reveal the formation of complex. The nonspecific interactions as well as those essential for biological activity are discussed along with its medicinal importance.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | 4'-epiadriamycin-d(CGATCG)2 Complex; Nuclear Magnetic Resonance Spectroscopy; Time-resolved Fluorescence Measurement; Diffusion Ordered Spectroscopy and Restrained Molecular Dynamics |
| ID Code: | 15390 |
| Deposited On: | 13 Nov 2010 09:03 |
| Last Modified: | 14 Feb 2011 08:34 |
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