Reaction of polarized ketene S,N-acetals with bromoacetaldehyde diethyl acetal: synthesis of 1-substituted 3-acyl- and 3-nitro-2-methylthiopyrroles and 1,2-annulated 3-acylpyrroles

Gupta, Akhilesh K. ; Chakrasali, R. T. ; Ila, H. ; Junjappa, H. (1989) Reaction of polarized ketene S,N-acetals with bromoacetaldehyde diethyl acetal: synthesis of 1-substituted 3-acyl- and 3-nitro-2-methylthiopyrroles and 1,2-annulated 3-acylpyrroles Synthesis, 2 . pp. 141-142. ISSN 0039-7881

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Official URL: https://www.thieme-connect.com/ejournals/abstract/...

Related URL: http://dx.doi.org/10.1055/s-1989-27179

Abstract

A regiospecific route for 1-substituted 3-acyl- and 3-nitro-2-methylthiopyrroles 3a-l and the corresponding 1,2-annulated 3-acylpyrroles 5a-c has been developed by reaction of acyl- and nitroketene S,N-acetals 1a-l and 4a-c with bromoacetaldehyde diethyl acetal in dimethylformamide.

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