A new general regiocontrolled synthesis of highly substituted and condensed indoles via heteroaromatic annelation

Suresh, J. R. ; Patra, Pranab K. ; Ila, H. ; Junjappa, H. (1997) A new general regiocontrolled synthesis of highly substituted and condensed indoles via heteroaromatic annelation Tetrahedron, 53 (43). pp. 14737-14748. ISSN 0040-4020

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00404...

Related URL: http://dx.doi.org/10.1016/S0040-4020(97)00985-X

Abstract

A new general method for the synthesis of substituted and condensed indoles has been developed via heteroaromatic annelation involving base induced conjugate addition-elimination of 1-methylpyrrole-2-acetonitrile to various α-oxoketene acetals followed by cyclization of the resulting adducts in the presence of TsOH in refluxing benzene.

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ID Code:15297
Deposited On:13 Nov 2010 12:59
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