Demuth, Andreas ; Aharonowitz, Yair ; Bachmann, Till T. ; Blum-Oehler, Gabriele ; Buchrieser, Carmen ; Covacci, Antonello ; Dobrindt, Ulrich ; Emody, Levente ; van der Ende, Arie ; Ewbank, Jonathan ; Fernandez, Luis Angel ; Frosch, Matthias ; Garcia-del Portillo, Francisco ; Gilmore, Michael S. ; Glaser, Philippe ; Goebel, Werner ; Hasnain, Seyed E. ; Heesemann, Jurgen ; Islam, Khalid ; Korhonen, Timo ; Maiden, Martin ; Meyer, Thomas F. ; Montecucco, Cesare ; Oswald, Eric ; Parkhill, Julian ; Pucciarelli, M. Graciela ; Ron, Eliora ; Svanborg, Catharina ; Uhlin, Bernt Eric ; Wai, Sun Nyunt ; Wehland, Jurgen ; Hacker, Jorg (2008) Pathogenomics: an updated European research agenda Infection, Genetics and Evolution, 8 (3). pp. 386-393. ISSN 1567-1348
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S15671...
Related URL: http://dx.doi.org/10.1016/j.meegid.2008.01.005
Abstract
The emerging genomic technologies and bioinformatics provide novel opportunities for studying life-threatening human pathogens and to develop new applications for the improvement of human and animal health and the prevention, treatment, and diagnosis of infections. Based on the ecology and population biology of pathogens and related organisms and their connection to epidemiology, more accurate typing technologies and approaches will lead to better means of disease control. The analysis of the genome plasticity and gene pools of pathogenic bacteria including antigenic diversity and antigenic variation results in more effective vaccines and vaccine implementation programs. The study of newly identified and uncultivated microorganisms enables the identification of new threats. The scrutiny of the metabolism of the pathogen in the host allows the identification of new targets for anti-infectives and therapeutic approaches. The development of modulators of host responses and mediators of host damage will be facilitated by the research on interactions of microbes and hosts, including mechanisms of host damage, acute and chronic relationships as well as commensalisms. The study of multiple pathogenic and non-pathogenic microbes interacting in the host will improve the management of multiple infections and will allow probiotic and prebiotic interventions. Needless to iterate, the application of the results of improved prevention and treatment of infections into clinical tests will have a positive impact on the management of human and animal disease.
Item Type: | Article |
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Source: | Copyright of this article belongs to Elsevier Science. |
Keywords: | Comparative Genomics; Bacterial Pathogens; Antibiotic Resistances; Microbe-microbe Interactions; Host-microbe Interactions |
ID Code: | 15244 |
Deposited On: | 13 Nov 2010 13:04 |
Last Modified: | 17 May 2016 00:09 |
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