Synthesis of quinolizine derivatives

Abstract

The scope of the Sugasawa method for the synthesis of quinolizinium derivatives has been investigated. Several benzo, naphtho and naphthobenzo quinolizinium compounds have been synthesised in excellent yields, although the ring on which cyclisation was effected did not carry any activating substituents. The material embodied in this paper formed part of a thesis submitted to the University of Madras in January 1953 for the Degree of Master of Science. While this paper was in preparation our attention has been drawn to a publication by Sugasawa et al. in the J. Pharm. Soc. Jap., 72, No. 10, p. 1275, in which the synthesis of three of the compounds prepared by us in the course of this study are reported.