Genetics of larval urea tolerance in Drosophila melanogaster

Abstract

The genetic control of larval tolerance to urea, a nitrogenous waste-product occurring naturally in crowded Drosophila cultures, was investigated in a set of five laboratory populations of D. melanogaster that had been successfully subjected to selection for increased larval urea tolerance. Larva to adult survivorship and development time at three different levels of urea were assayed on the five selected populations, their five matched controls and a set of 10 F₁ hybrid populations derived from reciprocal crosses between pairs of selected and control populations. As expected from the results of previous studies, the selected populations exhibited greater larval tolerance to the toxic effects of urea, relative to their controls. Comparison of the hybrid and parental populations with respect to both survivorship and development time indicated that the genetic control of urea tolerance in the selected populations is largely dominant, and has a significant X-linked component. The data also suggested that females from the selected populations exercise a nongenetic maternal effect on the development time of their progeny, regardless of urea level.