An expedient protocol of the Biginelli dihydropyrimidine synthesis using carbonyl equivalents

Singh, Kamaljit ; Singh, Jasbir ; Deb, Prasant K. ; Harjit Singh, (1999) An expedient protocol of the Biginelli dihydropyrimidine synthesis using carbonyl equivalents Tetrahedron, 55 (44). pp. 12873-12880. ISSN 0040-4020

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00404...

Related URL: http://dx.doi.org/10.1016/S0040-4020(99)00760-7

Abstract

A one - pot condensation of perhydro-1,3 heterocycles - aldehyde equivalents with ethyl acetoacetate and ureas provides a convenient synthesis of the title compounds with a variety of substituents at C-4. Yields are equivalent or significantly higher than the conventional methods.

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