A conventent synthesis of functonalised heterocuclic enamines from alpha-thioiminium salts and active methylene compounds under solid-liquid PTC conditions

Abstract

Functionalised enanines constitute a category of synthetic intermediates useful in carbon, carbon bond formation reactions and have been procured through a variety of condensaticn and extrusion reactions. In one approach active methylene compounds have been condensed with lactin thioethers in the presence of a base at relatively higher temperature. In view of our interest in the synthesis of function alised enamines through sulphur extrusion reactions, we have studied the title reaction under non-hydrolytic solid-liquid PTC using solid KF(base)/TEBA(catalyst). A recent report on the sulphur extrusion of α-thio-iminium salts and their reactions with active methylene compounds prompts us to report our results.