Gupta, Sanjeev Kumar ; Bakhshi, Sameer ; Gupta, Ritu ; Kamal, Vineet Kumar ; Sahoo, Ranjit Kumar ; Sharma, Atul ; Kumar, Lalit (2019) Clinical outcome of cases with isolated MLPA finding of amplification of chromosome 21 genes (AMP21-MLPA) is similar to other cases of BCR-ABL1 negative pediatric B-cell acute lymphoblastic leukemia Clinical Lymphoma Myeloma and Leukemia, 19 . S199-S200. ISSN 2152-2650
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Official URL: https://doi.org/10.1016/j.clml.2019.07.052
Related URL: http://dx.doi.org/10.1016/j.clml.2019.07.052
Abstract
B-ALL patients with intrachromosomal amplification of chromosome 21 (iAMP21) have an inferior outcome with standard therapy, which improves markedly, when treated as high risk disease using intensive chemotherapy. The identification of three or more extra copies of RUNX1 gene on chromosome 21, by FISH, is used to define iAMP21. Multiplex ligation-dependent probe amplification (MLPA) is emerging as a high throughput screening assay for iAMP21 and may act as alternative to comparative genomic hybridization.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 142235 |
| Deposited On: | 22 Jan 2026 17:41 |
| Last Modified: | 22 Jan 2026 17:41 |
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