Giri, Sidhartha ; Kumar, Nirmal ; Dhanapal, Pavithra ; Venkatesan, Jayalakshmi ; Kasirajan, Anand ; Iturriza-Gomara, Miren ; John, Jacob ; Abraham, Asha Mary ; Grassly, Nicholas C ; Kang, Gagandeep (2018) Quantity of Vaccine Poliovirus Shed Determines the Titer of the Serum Neutralizing Antibody Response in Indian Children Who Received Oral Vaccine The Journal of Infectious Diseases, 217 (9). pp. 1395-1398. ISSN 0022-1899
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Official URL: https://doi.org/10.1093/infdis/jix687
Related URL: http://dx.doi.org/10.1093/infdis/jix687
Abstract
Replication of oral poliovirus vaccine (OPV) in the intestine (vaccine 'take') is associated with seroconversion and protection against poliomyelitis. We used quantitative PCR to measure vaccine shedding in 300 seronegative infants aged 6-11 months and in 218 children aged 1-4 years 7 days after administration of monovalent or bivalent OPV. We found the quantity of shedding correlated with the magnitude of the serum neutralizing antibody response measured at 21 or 28 days respectively. This suggests the immune response to OPV is on a continuum, rather than an all-or-nothing phenomenon, that depends on efficient vaccine virus replication.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to University of Chicago Press. |
| Keywords: | Poliovirus; Seroconversion; Shedding. |
| ID Code: | 141940 |
| Deposited On: | 29 Dec 2025 10:12 |
| Last Modified: | 29 Dec 2025 10:12 |
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