Parker, Edward P K ; Whitfield, Helena ; Baskar, Chudarkodi ; Giri, Sidhartha ; John, Jacob ; Grassly, Nicholas C ; Kang, Gagandeep ; Praharaj, Ira (2018) FUT2 Secretor Status Is Not Associated With Oral Poliovirus Vaccine Immunogenicity in South Indian Infants The Journal of Infectious Diseases, 219 (4). pp. 578-581. ISSN 0022-1899
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Official URL: https://doi.org/10.1093/infdis/jiy553
Related URL: http://dx.doi.org/10.1093/infdis/jiy553
Abstract
FUT2 determines whether histo-blood group antigens are secreted at mucosal surfaces. Secretor status influences susceptibility to enteric viruses, potentially including oral poliovirus vaccine (OPV). We performed a nested case–control study to determine the association between FUT2 genotype (single-nucleotide polymorphisms G428A, C302T, and A385T) and seroconversion among Indian infants who received a single dose of monovalent type 3 OPV. Secretor prevalence was 75% (89 of 118) in infants who seroconverted and 80% (97 of 122) in infants who did not seroconvert (odds ratio, 0.79; 95% confidence interval, .43–1.45). Our findings suggest that FUT2 genotype is not a key determinant of variation in OPV immunogenicity.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to University of Chicago Press. |
| Keywords: | Blood group; FUT2; Immunogenicity; OPV; Poliovirus; Secretor; Vaccine. |
| ID Code: | 141926 |
| Deposited On: | 29 Dec 2025 10:16 |
| Last Modified: | 29 Dec 2025 10:16 |
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