Protective Effect of Natural Rotavirus Infection in an Indian Birth Cohort

Gladstone, Beryl P. ; Ramani, Sasirekha ; Mukhopadhya, Indrani ; Muliyil, Jayaprakash ; Sarkar, Rajiv ; Rehman, Andrea M. ; Jaffar, Shabbar ; Gomara, Miren Iturriza ; Gray, James J. ; Brown, David W.G. ; Desselberger, Ulrich ; Crawford, Sue E. ; John, Jacob ; Babji, Sudhir ; Estes, Mary K. ; Kang, Gagandeep (2011) Protective Effect of Natural Rotavirus Infection in an Indian Birth Cohort New England Journal of Medicine, 365 (4). pp. 337-346. ISSN 0028-4793

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Official URL: https://doi.org/10.1056/NEJMoa1006261

Related URL: http://dx.doi.org/10.1056/NEJMoa1006261

Abstract

More than 500,000 deaths are attributed to rotavirus gastroenteritis annually worldwide, with the highest mortality in India. Two successive, naturally occurring rotavirus infections have been shown to confer complete protection against moderate or severe gastroenteritis during subsequent infections in a birth cohort in Mexico. We studied the protective effect of rotavirus infection on subsequent infection and disease in a birth cohort in India (where the efficacy of oral vaccines in general has been lower than expected).

Item Type:Article
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Deposited On:28 Dec 2025 04:41
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