Dixit, N. M. ; Perelson, A. S. (2006) The metabolism, pharmacokinetics and mechanisms of antiviral activity of ribavirin against hepatitis C virus Cellular and Molecular Life Sciences, 63 (7-8). pp. 832-842. ISSN 1420-682X
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Official URL: https://doi.org/10.1007/s00018-005-5455-y
Related URL: http://dx.doi.org/10.1007/s00018-005-5455-y
Abstract
Ribavirin, a broad spectrum antiviral agent, in conjunction with interferon forms the current standard of treatment for hepatitis C virus (HCV) infection in humans. While ribavirin alone fails to induce a significant antiviral response, in combination with interferon, ribavirin dramatically improves the long-term outcome of therapy. The predominant mechanism(s) of ribavirin action against HCV, are yet to be established. In this review, we examine the current status of our understanding of the metabolism, pharmacokinetics and mechanisms of the antiviral activity of ribavirin against HCV, all of which are central to the rational identification of improved treatment protocols.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Birkhauser-Verlag. |
| Keywords: | Mutagenesis; Treatment Response; Viral Dynamics; Mathematical Model; Monotherapy; Combination Therapy |
| ID Code: | 141497 |
| Deposited On: | 02 Dec 2025 05:27 |
| Last Modified: | 02 Dec 2025 05:27 |
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