Thattai, Mukund (2017) Organelle acidification: an ancient cellular leak detector BMC Biology, 15 (1). ISSN 1741-7007
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Official URL: https://doi.org/10.1186/s12915-017-0395-1
Related URL: http://dx.doi.org/10.1186/s12915-017-0395-1
Abstract
Intracellular membrane-bounded organelles of eukaryotic cells transiently contact the extracellular environment during endocytosis and secretion. Such contacts must be precisely timed to prevent leakage of cargo. I argue that early eukaryotes evolved organelle acidification as a way to detect and prevent leakage.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to BioMed Central Ltd. |
| Keywords: | Leak Detection; Early Eukaryotes; Intracellular Membrane-bounded Organelle; Optimal Activity Range; Endocytic Structures. |
| ID Code: | 140022 |
| Deposited On: | 02 Sep 2025 14:16 |
| Last Modified: | 02 Sep 2025 14:16 |
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