The design, synthesis and in vivo biological evaluations of [V(IV)O(2,6-pyridine diacetatato) (H₂O)₂] (PDOV): Featuring its prolonged glucose lowering effect and non-toxic nature

Abstract

The synthesis and characterization of a novel vanadyl complex, [V(IV)O(2,6-pyridine diacetatato)(H₂O)₂] (PDOV) is reported. The pH-controlled release of the complex from polymer coated mesoporous silica was demonstrated for possible oral administration; results showed that release at pH 2 was significantly lower than that at pH 7.4. The said complex was subsequently screened for possible anti-diabetic activity, via an in vivo dose-response study (intraperitoneal and oral supplementation of PDOV) for 90 days in streptozotocin (STZ) induced diabetic rats. The results revealed that over a 90 day period, intraperitoneal administration of PDOV (at a dose of 75 mg/kgbw) and oral administration of the PDOV (at a dose of 100 mg/kgbw) were effective in suppressing the hyperglycemic state in the diabetic subjects. Exposure to PDOV was found to have little impact on the insulin levels of diabetics; however improved urea, creatinine, AST and ALT levels were noted.