Suppressed transcript diversity and immune response in COVID-19 ICU patients: a longitudinal study.

Mehta, Priyanka ; Chattopadhyay, Partha ; Mohite, Ramakant ; D’Rozario, Ranit ; Bandopadhyay, Purbita ; Sarif, Jafar ; Ray, Yogiraj ; Ganguly, Dipyaman ; Pandey, Rajesh (2023) Suppressed transcript diversity and immune response in COVID-19 ICU patients: a longitudinal study. Life Science Alliance, 7 (1). e202302305. ISSN 2575-1077

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Official URL: https://doi.org/10.26508/lsa.202302305

Related URL: http://dx.doi.org/10.26508/lsa.202302305

Abstract

Understanding the dynamic changes in gene expression during Acute Respiratory Distress Syndrome (ARDS) progression in post-acute infection patients is crucial for unraveling the underlying mechanisms. Study investigates the longitudinal changes in gene/transcript expression patterns in hospital-admitted severe COVID-19 patients with ARDS post-acute SARS-CoV-2 infection. Blood samples were collected at three time points and patients were stratified into severe and mild ARDS, based on their oxygenation saturation (SpO2/FiO2) kinetics over 7 d. Decline in transcript diversity was observed over time, particularly in patients with higher severity, indicating dysregulated transcriptional landscape. Comparing gene/transcript-level analyses highlighted a rather limited overlap. With disease progression, a transition towards an inflammatory state was evident. Strong association was found between antibody response and disease severity, characterized by decreased antibody response and activated B cell population in severe cases. Bayesian network analysis identified various factors associated with disease progression and severity, viz. humoral response, TLR signaling, inflammatory response, interferon response, and effector T cell abundance. The findings highlight dynamic gene/transcript expression changes during ARDS progression, impact on tissue oxygenation and elucidate disease pathogenesis.

Item Type:Article
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ID Code:138848
Deposited On:01 Sep 2025 07:39
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