Jayakrishnan, A. ; Chitambara Thanoo, B. ; Rathinam, K. ; Ravi Mandalam, K. ; Rao, V. R. K. ; Lal, A. V. ; Mohanty, Mira (1989) Hydrogel microspheres from crosslinked poly(methyl methacrylate): synthesis and biocompatibility studies Bulletin of Materials Science, 12 (1). pp. 17-25. ISSN 0250-4707
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Official URL: http://www.ias.ac.in/j_archive/bms/12/1/17-26/view...
Related URL: http://dx.doi.org/10.1007/BF02744590
Abstract
Smooth, perfectly spherical, highly hydrophilic microspheres have been prepared from crosslinked poly(methyl methacrylate) microspheres by alkaline hydrolysis in ethylene glycol at elevated temperatures. These microspheres absorb varying quantities of water depending upon the extent of hydrolysis. Subcutaneous implantation studies on rabbits demonstrated that the microspheres are biocompatible. Implantation studies in the renal arteries of dogs demonstrated the occlusion effect produced by the microspheres. Microspheres could be made radiopaque by the incorporation of barium sulphate. Potential uses envisaged for these microspheres in the biomedical area are that of artificial emboli for endovascular embolization and as microcarriers for the growth and propagation of anchorage dependent mammalian cells.
Item Type: | Article |
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Source: | Copyright of this article belongs to Indian Academy of Sciences. |
Keywords: | Microspheres; Artificial Emboli; Embolization; Biocompatibility; Hydrolysed PMMA Beads; Endovascular Occlusion |
ID Code: | 13882 |
Deposited On: | 12 Nov 2010 14:32 |
Last Modified: | 16 May 2016 22:58 |
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