Polymers with tunable side-chain amphiphilicity as non-hemolytic antibacterial agents

Uppu, Divakara S. S. M. ; Akkapeddi, Padma ; Manjunath, Goutham B. ; Yarlagadda, Venkateswarlu ; Hoque, Jiaul ; Haldar, Jayanta (2013) Polymers with tunable side-chain amphiphilicity as non-hemolytic antibacterial agents Chemical Communications, 49 (82). p. 9389. ISSN 1359-7345

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Official URL: https://doi.org/10.1039/C3CC43751E

Related URL: http://dx.doi.org/10.1039/C3CC43751E

Abstract

Quaternized polymers mimicking the antimicrobial peptides were created by tuning the side-chain amphiphilicity using a first-time approach of post-functionalization. They displayed excellent efficacy against pathogenic bacteria even in human plasma and membrane disruptive mode of action. The optimized polymers and degraded products were non-hemolytic.

Item Type:Article
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ID Code:138809
Deposited On:08 Sep 2025 04:33
Last Modified:08 Sep 2025 04:33

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