Ghosh, Chandradhish ; Sarkar, Paramita ; Samaddar, Sandip ; Uppu, Divakara S. S. M. ; Haldar, Jayanta (2017) L-Lysine based lipidated biphenyls as agents with anti-biofilm and anti-inflammatory properties that also inhibit intracellular bacteria Chemical Communications, 53 (60). pp. 8427-8430. ISSN 1359-7345
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Official URL: https://doi.org/10.1039/C7CC04206J
Related URL: http://dx.doi.org/10.1039/C7CC04206J
Abstract
L-Lysines were conjugated to lipidated biphenyls using simple synthetic chemistry to obtain selective membrane-active antibacterial agents that inhibit cell-wall biosynthesis. The most selective compound bore promising activity against biofilm-related infections and intracellular bacteria, and also suppressed the stimulation of TNF-α induced by lipoteichoic acid. Belligerent to resistance development, it was active in a murine model of MRSA infection.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Royal Society of Chemistry. |
| ID Code: | 138754 |
| Deposited On: | 05 Sep 2025 09:01 |
| Last Modified: | 05 Sep 2025 09:01 |
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