Goel, Harsh ; Chopra, Anita ; Ranjan, Amar ; Viswanathan, Ganesh Kumar ; Gupta, Aditya Kumar ; Meena, Jagdish Prasad ; Bakhshi, Sameer ; Khan, Maroof Ahmad ; Tanwar, Pranay (2021) AML-237: Wilms Tumor 1 (WT-1) Gene Methylation as an Epigenetic Biomarker in Acute Myeloid Leukemia Clinical Lymphoma Myeloma and Leukemia, 21 . S293-S294. ISSN 2152-2650
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Official URL: https://doi.org/10.1016/S2152-2650(21)01701-8
Related URL: http://dx.doi.org/10.1016/S2152-2650(21)01701-8
Abstract
Acute myeloid leukemia (AML) is a highly heterogeneous hematological malignancy characterized by different genetic and epigenetic aberrations. Several epigenetics modifications were observed in the promoter regions of the cellular epigenome, including hypomethylation or hypermethylation of CpG islands during the onset and progression of AML. DNA methylation is an epigenetic modification that regulates gene expression and plays a pivotal role in tumorigenesis, including AML. Wilms tumor 1 (WT-1) is a transcription factor involved in the differentiation and proliferation of AML. The clinical relevance of WT-1 gene expression and its underlying epigenetic alterations has not been fully addressed in AML.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | AML; Wilms Tumor-1; Acute myeloid leukemia; Epigenetics |
| ID Code: | 138657 |
| Deposited On: | 21 Aug 2025 08:40 |
| Last Modified: | 21 Aug 2025 08:40 |
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