Pediatric Hodgkin Lymphoma: CT Features at Presentation, on Treatment and its Prognostic Significance

Abstract

Objective To evaluate the CT features of pediatric Hodgkin Lymphoma (HL) at presentation, on treatment and to identify the risk factors on CT for early relapse. Methods CT findings at presentation, during and at the end of the treatment were reviewed in 70 children (3–17 years) with HL treated over the period of 4 years. Clinical and radiological parameters were evaluated at presentation. The response to treatment was assessed on CT at mid treatment and end of the treatment to identify the potential risk factors that might predict relapse. Results CT features of the nodal and extra-nodal disease at presentation of pediatric HL were same as widely described. All patients achieved complete remission. Ten (7.0%) patients relapsed during the mean follow-up of 3.3 years. CT features at presentation, during or at the end of the treatment were not useful to identify the risk of relapse. Conclusions There is no identifiable risk factor s on CT that could predict relapse. Further, the stage of the disease at presentation and the histological subtypes were not predictive of risk of relapse.