Rijhwani, A. ; Sen, S. ; Gunasekaran, S. ; Ponnaiya, J. ; Balasubramanian, K. A. ; Mammen, K. E. (1995) Allopurinol reduces the severity of peritoneal adhesions in mice Journal of Pediatric Surgery, 30 (4). pp. 533-537. ISSN 0022-3468
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/002234...
Related URL: http://dx.doi.org/10.1016/0022-3468(95)90124-8
Abstract
A study was designed to investigate the possibility of reducing peritoneal adhesion formation in mice by pretreatment with allopurinol. Allopurinol, at a dose of 35 mg/kg of body weight/d significantly reduced the severity of peritoneal adhesions (P < .001), and also the neutrophil response to ischemia (P < .05). Tissue myeloperoxidase activity at the site of ischemic injury was significantly lower in the allopurinol-treated mice at the end of 2 weeks (P < .001). However, xanthine oxidase was undetectable in both control and allopurinol-treated mice. These observations suggest that allopurinol reduces the severity of peritoneal adhesion formation in mice, possibly by reducing the neutrophil response to ischemia.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 1385 |
| Deposited On: | 05 Oct 2010 12:50 |
| Last Modified: | 14 May 2011 05:13 |
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