Surve, Chaitali ; Banerjee, Ananya ; S, Anupriya ; Chakraborty, Rajasree ; Kumar, Dhiraj ; Butti, Ramesh ; Gorain, Mahadeo ; Parida, Sabyasachi ; Kundu, Gopal C ; Shidhaye, Supriya ; Patnaik, Srinivas (2022) Antiproliferative and apoptotic potential of methotrexate lipid nanoparticles in a murine breast cancer model Nanomedicine, 17 (11). pp. 753-764. ISSN 1743-5889
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Official URL: https://doi.org/10.2217/nnm-2021-0446
Related URL: http://dx.doi.org/10.2217/nnm-2021-0446
Abstract
Aim: To evaluate the efficacy of novel methotrexate-loaded nanoparticles (MTX-NPs) in vitro and in vivo in the treatment of breast cancer. Materials & methods: MTX-NPs were tested for cellular uptake, cell viability, cell cycle, cellular wound migration and changes in tumor volume using characterized NPs. Results: The solid lipid NPs (SLNPs) showed strong cellular uptake, increased apoptosis, controlled cytotoxicity at lower IC50 of methotrexate and a sizable reduction in tumor burden. Conclusion: MTX-NP oral formulation can be a promising candidate in breast cancer treatment with improved cellular uptake and in vivo efficacy.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Future Medicine. |
| Keywords: | Breast cancer; Methotrexate; Methotrexate-loaded nanoparticles; Solid lipid nanoparticles |
| ID Code: | 138484 |
| Deposited On: | 26 Aug 2025 06:46 |
| Last Modified: | 26 Aug 2025 06:46 |
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