Ahmed, Mansoor ; Behera, Reeti ; Chakraborty, Goutam ; Jain, Shalini ; Kumar, Vinit ; Sharma, Priyanka ; Bulbule, Anuradha ; Kale, Smita ; Kumar, Santosh ; Mishra, Rosalin ; Raja, Remya ; Saraswati, Supriya ; Kaur, Rajinder ; Soundararajan, Gowrishankar ; Kumar, Dhiraj ; Thorat, Dhanashri ; Sanyal, Megha ; Ramdasi, Anuja ; Ghosh, Pompom ; Kundu, Gopal C (2011) Osteopontin: a potentially important therapeutic target in cancer Expert Opinion on Therapeutic Targets, 15 (9). pp. 1113-1126. ISSN 1472-8222
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Official URL: https://doi.org/10.1517/14728222.2011.594438
Related URL: http://dx.doi.org/10.1517/14728222.2011.594438
Abstract
Cancer is an extremely complex disease and most cancer treatments are limited to chemotherapy, radiation and surgery. The progression of tumours towards malignancy requires the interaction of various cytokines, growth factors, transcription factors and effector molecules. Osteopontin is a cytokine-like, calcium-binding, extracelular-matrix- associated member of the small integrin-binding ligand, N-linked glycoprotein (SIBLING) family of proteins. It plays an important role in determining the oncogenic potential of various cancers. The role of osteopontin in various pathophysiological conditions suggests that the alteration in post-translational modification result in different functional forms that might change its normal physiological functions.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Informa plc. |
| Keywords: | angiogenesis; Metastasis; Osteopontin; Prognostic markertargeted; Therapytumour-stroma interaction. |
| ID Code: | 138440 |
| Deposited On: | 22 Aug 2025 12:31 |
| Last Modified: | 22 Aug 2025 12:31 |
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