Gupta, Nidhi ; Gupta, Ritu ; Sharawat, Surender Kumar ; Bakhshi, Sameer (2010) Childhood Chronic Myeloid Leukemia with Monocytosis The Indian Journal of Pediatrics, 77 (10). pp. 1143-1145. ISSN 0019-5456
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Official URL: https://doi.org/10.1007/s12098-010-0200-4
Related URL: http://dx.doi.org/10.1007/s12098-010-0200-4
Abstract
We report two cases of chronic myeloid leukemia (CML) in childhood presenting with monocytosis. History, physical examination and laboratory findings were in favor of juvenile myelomonocytic leukemia in both the cases, but reverse transcriptase polymerase chain reaction (RT-PCR) detected b2a2 and b3a2 transcript of p210 bcr-abl protein characteristic of major BCR breakpoint. Presence of monocytosis in early childhood suggests a viral infection or JMML but a possibility of CML with monocytosis needs to be considered.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Dr. K.C. Chaudhuri Foundation. |
| Keywords: | CML; Monocytosis; Major BCR breakpoint. |
| ID Code: | 138064 |
| Deposited On: | 19 Aug 2025 10:43 |
| Last Modified: | 19 Aug 2025 10:43 |
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