Sharawat, Surender Kumar ; Bakhshi, Radhika ; Vishnubhatla, Sreenivas ; Gupta, Ritu ; Bakhshi, Sameer (2014) Flt3-itd mutation in relation to flt3 expression in pediatric aml: a prospective study from India Pediatric Hematology and Oncology, 31 (2). pp. 131-137. ISSN 0888-0018
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Official URL: https://doi.org/10.3109/08880018.2013.870624
Related URL: http://dx.doi.org/10.3109/08880018.2013.870624
Abstract
There is lack of data with regard to FLT3 expression in FLT3-ITD positive pediatric AML patients. Further, FLT3-ITD has not been systematically analyzed for outcome from Indian subcontinent. Amongst 64 consecutive pediatric AML patients, FLT3-ITD was present in 12 (19%) patients. All patients with FLT3-ITD achieved CR; those with FLT3-ITD mutation had inferior DFS (P = .029). FLT3 expression by flow-cytometry was observed in all FLT3-ITD positive patients, whereas 40/52 (77%) FLT3-ITD negative patients expressed FLT3 (P = .06). FLT3 expression in 12 FLT3-ITD positive patients was unable to show an association between FLT3 expression and outcome. In FLT3-ITD negative patients, higher surface expression of FLT3 significantly predicted poor EFS (P = .001) and OS (P = .007).
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Informa Healthcare. |
| Keywords: | Acute myeloid leukemia; FLT3 Expression; FLT3-ITD Mutation; Pediatric; Prognosis. |
| ID Code: | 138061 |
| Deposited On: | 19 Aug 2025 10:37 |
| Last Modified: | 19 Aug 2025 10:37 |
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