Sahoo, Subhasish ; ur Rehman, Jawad ; Shah, Muhammad Raza ; De, Priyadarsi ; Tecilla, Paolo (2021) Cholate conjugated polymeric amphiphiles as efficient artificial ionophores. ACS Applied Polymer Materials, 3 (2). pp. 588-593. ISSN 2637-6105
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Official URL: https://doi.org/10.1021/acsapm.0c01182
Related URL: http://dx.doi.org/10.1021/acsapm.0c01182
Abstract
A family of amphiphilic copolymers containing hydrophobic cholate pendants has been prepared by copolymerization of cholic acid-based monomer 2-(methacryloxy)-ethyl cholate (MAECA) with polyethylene glycol methyl ether methacrylate (PEGMA). The polymers differ for the content of MAECA that increases from 0 to 35%. The copolymers partition within liposomes and display potent ionophoric activity forming large pores in the membrane and allowing the leakage of small inorganic ions (H+, Na+) and of large polar organic molecules (calcein). Their activity is strictly correlated to the content of cholic acid subunits, increasing as the fraction of cholate moiety increases.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| ID Code: | 137981 |
| Deposited On: | 29 Aug 2025 10:17 |
| Last Modified: | 29 Aug 2025 10:17 |
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