Paul, Soumya ; Pan, Swagata ; Chakraborty, Ayan ; De, Priyadarsi ; Mukherjee, Arindam (2021) Ultraviolet light- or ph-triggered nitric oxide release from a water-soluble polymeric scaffold. ACS Applied Polymer Materials, 3 (5). pp. 2310-2315. ISSN 2637-6105
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Official URL: https://doi.org/10.1021/acsapm.0c01375
Related URL: http://dx.doi.org/10.1021/acsapm.0c01375
Abstract
To develop nitric oxide (NO)-releasing donors, we synthesized N-nitrosamine-functionalized water-soluble alternating copolymer as a macromolecular scaffold with a high half-life. A reversible addition–fragmentation chain transfer polymerization of maleic anhydride (MA) and styrene (S) using poly(ethylene glycol) methyl ether (mPEG) containing macro-chain transfer agent (mPEG-CDP) (CDP = 4-cyano-(dodecylsulfanylthiocarbonyl)sulfanyl pentanoic acid) produced the mPEG-b-P(MA-alt-S) polymeric scaffold, which was further modified with NO binding motifs. NO detection performed by Griess assay and 1,2-diaminoanthraquinone demonstrated a controlled release of NO from the polymer in acidic pH or with 254 nm UV light.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| ID Code: | 137971 |
| Deposited On: | 29 Aug 2025 08:42 |
| Last Modified: | 29 Aug 2025 08:42 |
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