Tilak, TVSVGK ; Sherawat, Surender ; Agarwala, Sandeep ; Gupta, Ritu ; Vishnubhatla, Sreenivas ; Bakhshi, Sameer (2014) Circulating t-regulatory cells in neuroblastoma: a pilot prospective study Pediatric Hematology and Oncology, 31 (8). pp. 717-722. ISSN 0888-0018
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Official URL: https://doi.org/10.3109/08880018.2014.886002
Related URL: http://dx.doi.org/10.3109/08880018.2014.886002
Abstract
The objective of our study was to determine baseline Tregs in neuroblastoma patients and correlate with patient characteristics, their change with therapy and at relapse/progression. Flow-cytometric analysis for Treg cells [CD4+CD25+FoxP3+] was done in 14 de novo neuroblastoma patients at diagnosis, post-neoadjuvant chemotherapy and at relapse/progression, along with six healthy controls. Patients had significantly higher baseline Treg frequency than controls [Mean 9.84 ± 3.84 vs 3.16 ± 1.49, P < .001]; higher mean Treg frequency in patients with tumors >10 cm (P = .004) and there was significant reduction in Treg frequency with neoadjuvant chemotherapy when compared with the baseline value [Mean 3.07 ± 1.24 vs 9.72 ± 3.84, P = .007].
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Informa Healthcare. |
| Keywords: | Chemotherapy; Neuroblastoma; T-Regulator |
| ID Code: | 137796 |
| Deposited On: | 18 Aug 2025 11:36 |
| Last Modified: | 18 Aug 2025 11:36 |
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