Panteleev, P. V. ; Bolosov, I. A. ; Khokhlova, V. A. ; Dhanda, G. ; Balandin, S. V. ; Haldar, Jayanta ; Ovchinnikova, T. V. (2022) Analysis of antibacterial action of mammalian host-defense cathelicidins and induction of resistance to them in MβL-producing Pseudomonas aeruginosa Bulletin of Experimental Biology and Medicine, 172 (4). pp. 447-452. ISSN 0007-4888
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Official URL: https://doi.org/10.1007/s10517-022-05411-8
Related URL: http://dx.doi.org/10.1007/s10517-022-05411-8
Abstract
Recombinant analogs of a number of natural host-defense mammalian cathelicidins were obtained and predominant mechanism of their antibacterial action was studied. The ability of cathelicidins to suppress the growth of Pseudomonas aeruginosa producing metallo-β-lactamases (MβL) was studied, and the possibility of appearance of cathelicidin-resistant bacteria was evaluated. Among peptides with different structures and mechanisms of action, only the strains resistant to ChMAP-28 were not obtained, which indicated minimum risk of the development of natural resistance to this cathelicidin. High antibacterial activity, wide spectrum of action, and the absence of cross-resistance effects allow considering ChMAP-28 peptide as a candidate to be developed further as a therapeutic agent against MβL-producing bacteria.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Springer Nature Limited. |
| Keywords: | Antimicrobial Peptides; Cathelicidins; Resistance; Metallo-β-Lactamases (MβL); Gram-Negative Bacteria |
| ID Code: | 137700 |
| Deposited On: | 05 Sep 2025 06:02 |
| Last Modified: | 05 Sep 2025 06:02 |
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