Jeancolas, Cyrille ; Matsubara, Yoshiya J. ; Vybornyi, Mykhailo ; Lambert, Camille N. ; Blokhuis, Alex ; Alline, Thomas ; Griffiths, Andrew D. ; Ameta, Sandeep ; Krishna, Sandeep ; Nghe, Philippe (2021) RNA diversification by a self-reproducing ribozyme revealed by deep sequencing and kinetic modelling Chemical Communications, 57 (61). pp. 7517-7520. ISSN 1359-7345
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Official URL: https://doi.org/10.1039/D1CC02290C
Related URL: http://dx.doi.org/10.1039/D1CC02290C
Abstract
We demonstrate that a recombinase ribozyme achieves multiple functions in the same reaction network: self-reproduction, iterative elongation and circularization of other RNAs, leading to synthesis of diverse products predicted by a kinetic model. This shows that key mechanisms can be integrated and controlled toward Darwinian evolution in RNA reaction networks.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Royal Society of Chemistry. |
| ID Code: | 137635 |
| Deposited On: | 09 Sep 2025 11:25 |
| Last Modified: | 09 Sep 2025 11:25 |
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