Chaudhary, Shilpi ; Ganguly, Shuvadeep ; Palanichamy, Jayanth Kumar ; Singh, Archna ; Bakhshi, Radhika ; Jain, Ayushi ; Chopra, Anita ; Bakhshi, Sameer (2021) PGC1A driven enhanced mitochondrial DNA copy number predicts outcome in pediatric acute myeloid leukemia Mitochondrion, 58 . pp. 246-254. ISSN 1567-7249
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Official URL: https://doi.org/10.1016/j.mito.2021.03.013
Related URL: http://dx.doi.org/10.1016/j.mito.2021.03.013
Abstract
Mitochondrial DNA (mtDNA) copy number alterations occur in acute myeloid leukemia (AML). We evaluated regulation and biological significance of mtDNA copy number in pediatric AML patients (n = 123) by qRT-PCR, and in-vitro studies. MtDNA copy number was significantly higher (p < 0.001) and an independent predictor of aggressive disease (p = 0.006), lower event free survival (p = 0.033), and overall survival (p = 0.007). Expression of TFAM, POLG, POLRMT, MYC and ND3 were significantly upregulated. In cell lines, PGC1A inhibition decreased mtDNA copy number while MYC inhibition had no effect. PGC1A may contribute to enhanced mtDNA copy number, which predicts disease aggressiveness and inferior survival outcome.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 137587 |
| Deposited On: | 18 Aug 2025 07:48 |
| Last Modified: | 18 Aug 2025 07:48 |
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