Evaluation of gum odina/carbopol composite mucoadhesive hydrogel on pharmaceutical performance: Focusing on potential periodontal treatment

Abstract

Antimicrobial buccal hydrogel made of polymers have gained tremendous utilisation in biomedical field. Dual drug loaded, porous materials are important areas of research for medical and pharmaceutical industries. In this regard, a series of hydrogels (F1, F2, F3) were prepared with gum odina and carbopol 940 in aqueous solution with calcium chloride as the cross linker and glycerol as plasticizer by ionotropic gelation method. The buccal hydrogel was evaluated for thermal stability (TGA/DSC) revealing them to be thermally stable. The SEM and AFM studies of the optimized formulation (F2) exhibits cracks and porous structure. It also depicted good injectability and self-healing. The XRD result displayed amorphous nature of the formulation (F2) making them soluble in buccal fluids. The chemical nature and interactions were analysed by FTIR study. The release profile portrayed controlled release patterns for amoxicillin trihydrate and fluconazole. Appreciable mucoadhesion time (6 ± 0.7 h) and strength (12.03 ± 0.45 g) was observed in case of F2. The optimized formulation F2 displayed good antifungal and antibacterial properties. Thus, it is concluded that the hydrogel formed were mucoadhesive and highly potent to carry drug molecules for controlled release in the buccal mucosa to treat several periodontal infections.